Study examines disruption of circadian rhythm in dairy cows as risk factor fordecreased insulin sensitivity, mammary development, and milk yield

Study examines disruption of circadian rhythm in dairy cows as risk factor for decreased insulin sensitivity, mammary development, and milk yield

Maintaining consistency in day-to-day activities and environment is important for dairy cows during late gestation, according to a study published in Journal of Dairy Science®.

Anyone who has ever suffered from jet lag knows you can’t disrupt your normal sleep schedule without physiological effects. New research in lactating dairy cattle demonstrates that changing natural circadian rhythms can cause decreased mammary development and increased insulin resistance, which may lead to lower subsequent milk yield. The research, presented in the Journal of Dairy Science, is helping scientists better understand how circadian and metabolic systems are connected and mutually managed.

The highest rate of metabolic disease in dairy cattle happens in the period at the end of gestation and for the first few months after delivery. In mammals, the circadian timing system is composed of multiple clocks. The master clock is located in the suprachiasmatic nuclei of the hypothalamus, and regulates the timing of peripheral clocks across the body. Changes in the timing of temporal cues in an animal’s environment disturb daily physiological and behavioral cycles and are linked to negative changes in metabolic systems that can affect health in rodents and humans.

“This work indicates that the circadian timing system plays a role in the regulation of glucose homeostasis and mammary development in cattle and shows the importance of minimizing disturbances in day-to-day activities and environment of cattle and maintaining consistency during late gestation to ensure optimal milk production in early lactation,” said author Theresa Casey, PhD, Department of Animal Sciences, Purdue University.

Casey and her colleagues exposed Holstein cows to 16 hours of light and 8 hours of darkness, with the light cycle shifting 6 hours every 3 days, starting 35 days before the animals were expected to calve. After five weeks of exposure, cows in late pregnancy exhibited increased insulin resistance and reduced mammary development compared with the control group. The researchers found that the effects carried over into the postpartum period, after the treatment was eliminated, and cows had reduced milk yield and decreased insulin sensitivity.

Because major shifts occur in how dietary energy is directed to support fetal growth and milk synthesis during the transition from late gestation to early lactation, this is the most metabolically demanding time for dairy cattle. The scientists zeroed in on the levels of blood glucose, insulin, nonesterified fatty acids, and β-hydroxybutyrate, which are the markers for changes in plasma metabolite and hormone levels that reflect physiological changes in response to increased metabolic demands.

Jacquelyn Boerman, PhD, Department of Animal Sciences, Purdue University, added, “Dairy farm management systems need to consider approaches that minimize the potential of circadian system disruption for the benefit of cattle health and production.”

Research was supported by the Agriculture and Food Research Initiative competitive grant from the USDA National Institute of Food and Agriculture.

 

Source: Journal of Dairy Science

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