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Newly Discovered Haplotype Affects Holstein Calves
August 20, 2015

German researchers recently identified a new haplotype that affects holstein calves known as haplotype associated with Cholesterol Deficiency (HCD). Homozygous animals are born with no cholesterol and survive only a few months.


Heterozygotes have reduced cholesterol and survive only a few months. Heterozygotes have reduced cholesterol. The particular haplotype carrying the defect is difficult to track because a normal version and a recently mutated version are both frequent. 

To learn more about where this haplotype traces back to, click here. CDCB identifies animals on a 0-4 scale.

0. Non-carrier: free of HCD
1. Carrier: haplotype confirmed with pedigree information
2. Homozygous: confirmed on both sides of pedigree
3. Suspect carrier: haplotype origin could not be confirmed from pedigree
4. Suspect homozygous: probable carrier and may be homozygous; origin of haplotypes could not be confirmed from pedigree

Listed below are the small portion of the Accelerated Genetics active marketed line-up that are confirmed carriers of HCD.

  •  014HO07627 Sanders HCD1
  •  014HO07464 Dusk HCD1
  •  534HO00032 Kool HCD1
  •  534HO00010 Cashcoin HCD1
  •  534HO00009 Cashmoney HCD1
  •  014HO07449 Ocean Pp HCD1
  •  534HO00021 Prodigy-Red HCD1

The Accelerated Genetics website can be your trusted first choice to identify sires impacted with HCD across all studs. Below is a step by step of how to do so.

  1. Visit the Accelerated Genetics advanced search by clicking here.
  2. Click the red “advanced search” button.
  3. Click the “Status/Studs ” tab. A list of traits and boxes should appear
  4. In the second column, the fourth option down is Haplo Types, check the box to the right of it so that it turns blue with a checkbox in it.
  5. In the third column below the header Marketing Organization, check the box next to all studs.
  6. Then click search.
  7. After you click on the search box, sires from all studs will appear. A column called Haplo_Type will appear on the far right side that show which Haplotypes each bull is identified with.

    Chelsey Johnson, Accelerated Genetics


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